Inter Miami will miss midfielder Baltasar Rodriguez until mid-June, with David Ruiz and Yannick Bright also sidelined due to injuries.

Veteran Sergio Busquets might partner with Federico Redondo in midfield, supporting forwards Lionel Messi and Luis Suarez.

With goalkeeper Drake Callender and center-back Gonzalo Lujan unavailable, fans may see central defenders Noah Allen and Maximiliano Falcon partnering in front of shot-stopper Oscar Ustari.

For Columbus Crew, wing-back Mohamed Farsi is dealing with a back injury, while goalkeeper Patrick Schulte and center-backs Sean Zawadzki and Rudy Camacho are also out.

Steven Moreira, Yevhen Cheberko, and Malte Amundsen could be responsible for protecting goalkeeper Nicholas Hagen.

The visitors might deploy a double pivot of Darlington Nagbe and Dylan Chambost, positioned behind an attacking trio of Diego Rossi, Daniel Gazdag, and Ibrahim Aliyu.

Inter Miami possible starting lineup:

Ustari; Fray, Falcon, Allen, Alba; Allende, Redondo, Busquets, Segovia; Messi, Suarez

Columbus Crew possible starting lineup:

Hagen; Moreira, Cheberko, Amundsen; Herrera, Chambost, Nagbe, Arfsten; Rossi, Gazdag; Aliyu