Just a couple of weeks after the Arsenal Women’s team staged a thrilling comeback against Real Madrid in the Champions League quarter - final, it’s now the men’s team’s turn to replicate the women’s remarkable 3-0 victory at the Emirates Stadium. This match is, without a doubt, the most significant one for Mikel Arteta during his tenure as the manager so far.

Arteta, a former Barcelona youth academy graduate, ended Arsenal’s long - suffering absence from the Champions League quarter - finals last year. This season, he has once again guided the team to the last eight. The Gunners achieved this by thrashing PSV 7-1 in the first leg of the round - of - 16 tie. Later, they played out a relatively comfortable 2-2 draw at home in the second leg.

Arsenal defied their attacking absences in their first-leg slaughter of the Dutch side, but after scoring seven in just 90 minutes at the Philips Stadion, they have now only managed an identical number in their last five games, further hampering their already wafer-thin hopes of Premier League glory.

A low-key 1-1 draw with Everton on Saturday inched Liverpool closer to the title, although Arteta's team selection was that of a man with all eyes firmly on Madrid, where Arsenal will endeavour to stretch their unbeaten run across all tournaments to eight games while also maintaining an exceptional European home record.

Indeed, the North London giants have avoided defeat in each of their last 10 Champions League games at the Emirates - securing eight clean sheets in that time - and Real Madrid's preparations for their first-ever competitive game at the stadium have been anything but ideal.

For as long as the stoic Carlo Ancelotti mans the Real Madrid touchline, Los Blancos will ostensibly always find a way in the Champions League, and so it proved in the second leg of their closely-contested last-16 showdown with city rivals Atletico Madrid.

Rocked in the first minute by a Conor Gallagher opener, the 15-time European Cup winners relied on their 12-yard prowess to make the quarter-finals for the fifth year running, and Gooners could be forgiven for glossing over their opponents' record at this point.

Not since the 2003-04 season have Real Madrid been knocked out in the quarter-final stage - winning each of their last 12 two-legged ties at this juncture - but Ancelotti's men have been humbled ever so slightly in their last two domestic outings.

After shipping four to Real Sociedad in the second leg of their Copa del Rey semi-final - but still advancing to an El Clasico final with a 5-4 aggregate win - Real Madrid suffered a shock 2-1 La Liga defeat to Valencia over the weekend, as Hugo Duro headed home an extraordinary 95th-minute winner at the Bernabeu.

Of course, Arsenal are no strangers to Madrid masterclasses - Thierry Henry's sensational solo goal from their 1-0 win in 2006 will no doubt be played on repeat from now until kickoff - and a 0-0 draw at Highbury in the return leg means that the Gunners have never lost to Real Madrid in a competitive game.

It is never too late for revenge in football, though, and if Real Madrid can make Arsenal the 112th different team they have beaten in the Champions League on Tuesday night, another trophy-less season will await Arteta's Arsenal barring a miraculous second-leg turnaround.

A quartet of long-term Arsenal absentees - Gabriel Jesus (knee), Kai Havertz (hamstring), Takehiro Tomiyasu (knee) and Gabriel Magalhaes (hamstring) - will watch on helplessly this week, as will versatile defender Riccardo Calafiori and the banned Raheem Sterling.

However, Arteta allayed fears over a new issue for makeshift striker Mikel Merino at Goodison Park; the Spaniard suffered a cut to his head but should be given the green light to line up in a Bukayo Saka-reinforced attack.

The Hale End hero has come through two substitute cameos unscathed since returning from a hamstring problem and is now expected to make his first start of 2025, returning to the first XI alongside the likes of Thomas Partey, Jurrien Timber, Martin Odegaard and Gabriel Martinelli.

While Sterling's suspension for Arsenal should not prove too costly, Real Madrid will have to make do without the integral Aurelien Tchouameni, also banned for the first leg at the Emirates on account of an accumulation of yellow cards.

The Frenchman takes his place on the sidelines with Dani Carvajal and Eder Militao - both out for the season with knee problems - but Ferland Mendy (muscle), Thibaut Courtois (muscle) and one-time Gunner Dani Ceballos (calf) are expected to shake off the issues that forced them to miss the Valencia defeat.

Ancelotti had no choice but to start 19-year-old goalkeeper Fran Gonzalez at the weekend, as number two Andriy Lunin was also struggling with a calf complaint, but the Ukrainian will guard the sticks here if Courtois does not pass a late fitness test.

However, fears that Kylian Mbappe, Ceballos, Antonio Rudiger and Vinicius Junior would miss the first leg due to suspension did not come to fruition, as they escaped with fines after a UEFA investigation into their celebrations against Atletico.

Arsenal possible starting lineup:

Raya; Timber, Saliba, Kiwior, Lewis-Skelly; Odegaard, Partey, Rice; Saka, Merino, Martinelli

Real Madrid possible starting lineup:

Courtois; Vazquez, Asencio, Rudiger, Mendy; Valverde, Camavinga; Rodrygo, Bellingham, Vinicius Jr; Mbappe