Real Betis will be without the injured players Hector Bellerin, Diego Llorente, Marc Roca, and Chimy Avila.

Additionally, the availability of Youssouf Sabaly, Johnny Cardoso, and Francisco Vieites remains uncertain.

Manager Pellegrini is expected to rest key players such as Isco and Anthony in preparation for next week's Conference League final against Chelsea.

Players like William Carvalho and Cucho Hernandez may start, as they are not registered for Conference League participation.

For Valencia, long-term absentee Thierry Correia will still be unavailable, and Lopez's status is in question after he was substituted due to a hamstring injury over the weekend.

Defender Dimitri Foulquier is also doubtful for the match, having missed the last two games because of illness.

Goalkeeper Giorgi Mamardashvili is poised to play his final game for Valencia before joining Liverpool in the upcoming summer transfer window.

Ivan Jaime might step in if Lopez is unfit, while Duro is set to return to the starting lineup, aiming to build on his 11-goal league tally this season.

Real Betis possible starting lineup:

Adrian, Ortiz, Bartra, Mendy, Perraud; Carvalho, Altimira; Abde, Lo Celso, Rodriguez; Cucho

Valencia possible starting lineup:

Mamardashvili; Mosquera, Diakhaby, Tarrega, Gaya; Rioja, Barrenechea, Guerra, Jaime; Almeida, Duro