Betis are continuing to dream of winning their first-ever European trophy after negotiating two knockout rounds following their 15th-place finish in the league phase.

They recorded a 3-1 aggregate win over Gent in the knockout round playoff, before they saw off Vitoria Guimaraes in the last-16 despite being held to a 2-2 draw in the home leg.

Los Verdiblancos cruised to a 4-0 victory in the return leg in Portugal to seal their spot in a European quarter-final for the first time since losing 5-2 on aggregate to Chelsea in the last-eight stage of the 1997-98 UEFA Cup Winners' Cup.

Manuel Pellegrini's side will head into Thursday's fixture in a confident mood after putting together an eight-game unbeaten run in all competitions and a seven-match undefeated streak in La Liga.

In fact, they recorded six consecutive league victories before they held leaders Barcelona to a 1-1 draw in Saturday's away clash, which saw Natan score his first La Liga goal to cancel out Gavi's opener, leaving Betis in sixth spot and level on points with Villarreal in fifth position.

As Betis turn their focus to Conference League action, they can draw inspiration from the fact they have suffered a first-leg defeat in just three of their last 17 two-legged ties in European competition.

Jagiellonia have already made history in the Conference League this season, with the Polish side competing in the knockout rounds for the very first time after finishing in ninth position in the league phase, where they missed out on a top-eight place due to goal difference.

They made light work of their maiden European knockout round tie against TSC, recording 3-1 victories in home and away legs to set up a last-16 clash with Cercle Brugge.

After claiming a 3-0 win in the first leg against 10-man Cercle, Jagiellonia were given a scare in the away leg when they conceded two goals in 50 minutes.

However, they ultimately stood firm for the remainder of the contest to advance to the quarter-finals, with Adrian Siemieniec's side now set to battle Betis for the right to face either Celje or Fiorentina in the final four.

Since their trip to Belgium, Jagiellonia have gone on to win two of their next four competitive matches (D1, L1), including a narrow 1-0 victory over Wisla Krakow earlier this month to win the Polish Super Cup for just the second time in the club's history.

Thursday's visitors have been defeated in two of their last three away games in the Conference League, although they have never lost an away first leg in any of their previous five two-legged European ties (W4, D1).

Real Betis possible starting lineup:

Vieites; Sabaly, Bartra, Llorente, Rodriguez; Cardoso, Fornals; Antony, Isco, Rodriguez; Bakambu

Jagiellonia Bialystok possible starting lineup:

Abramowicz; Wojtuszek, Skrzypczak, Ebosse, Moutinho; Flach, Romanczuk, Imaz; Miki, Churlinov, Pululu